Open AccessAngiopoietin-1 inhibits toll-like receptor 4 signalling in cultured endothelial cells: role of miR-146b-5p
Author(s) -
Raquel Echavarría,
Dominique Mayaki,
Jean-Charles Neel,
Sharon Harel,
Verónica Sánchez,
Sabah N. A. Hussain
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv120
Subject(s) - tlr4 , microbiology and biotechnology , transfection , receptor , cytokine , umbilical vein , inflammation , cell adhesion molecule , tumor necrosis factor alpha , interleukin 8 , innate immune system , downregulation and upregulation , tlr2 , signal transduction , immune system , chemistry , immunology , biology , cell culture , in vitro , biochemistry , genetics , gene
Bacterial lipopolysaccharides (LPS) induce innate immune inflammatory responses in endothelial cells by activating toll-like receptor 4 (TLR4) signalling. Here, we investigate the effects of angiopoietin-1 (Ang-1) on LPS-induced TLR4 signalling and the role of the miR-146 family of micro RNAs in the effects of Ang-1 on TRL4 signalling.
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