Open AccessRegulatory T cells in human and angiotensin II-induced mouse abdominal aortic aneurysms
Author(s) -
Yi Zhou,
Wilson Wu,
Jes S. Lindholt,
Galina K. Sukhova,
Peter Libby,
Xueqing Yu,
GuoPing Shi
Publication year - 2015
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvv119
Subject(s) - foxp3 , medicine , angiotensin ii , regulatory t cell , adoptive cell transfer , lesion , immunology , interleukin 10 , t cell , endocrinology , pathology , immune system , il 2 receptor , blood pressure
Regulatory T cells (Tregs) protect mice from angiotensin II (Ang-II)-induced abdominal aortic aneurysms (AAA). This study tested whether AAA patients are Treg-insufficient and the Treg molecular mechanisms that control AAA pathogenesis.
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