Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves | Zendy

Mathilda T.M. Mommersteeg | Zendy; Mason L. Yeh | Zendy; John G. Parnavelas | Zendy; William Andrews | Zendy

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Disrupted Slit-Robo signalling results in membranous ventricular septum defects and bicuspid aortic valves

Author(s) -

Mathilda T.M. Mommersteeg,

Mason L. Yeh,

John G. Parnavelas,

William Andrews

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv040

Subject(s) - bicuspid aortic valve , anatomy , heart development , cardiology , medicine , aortic valve , embryonic stem cell , biology , biochemistry , gene

The mesenchymal cushions lining the early embryonic heart undergo complex remodelling to form the membranous ventricular septum as well as the atrioventricular and semilunar valves in later life. Disruption of this process underlies the most common congenital heart defects. Here, we identified a novel role for Slit-Robo signalling in the development of the murine membranous ventricular septum and cardiac valves.

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