Decreasing mitochondrial fission diminishes vascular smooth muscle cell migration and ameliorates intimal hyperplasia | Zendy

Li Wang | Zendy; Tianzheng Yu | Zendy; Hakjoo Lee | Zendy; Dawn K. O'Brien | Zendy; Hiromi Sesaki | Zendy; Yisang Yoon | Zendy

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Decreasing mitochondrial fission diminishes vascular smooth muscle cell migration and ameliorates intimal hyperplasia

Author(s) -

Li Wang,

Tianzheng Yu,

Hakjoo Lee,

Dawn K. O'Brien,

Hiromi Sesaki,

Yisang Yoon

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv005

Subject(s) - mitochondrial fission , microbiology and biotechnology , intimal hyperplasia , mfn2 , vascular smooth muscle , mitochondrial fusion , mitochondrion , biology , chemistry , mitochondrial dna , endocrinology , biochemistry , smooth muscle , gene

Vascular smooth muscle cell (VSMC) migration in response to arterial wall injury is a critical process in the development of intimal hyperplasia. Cell migration is an energy-demanding process that is predicted to require mitochondrial function. Mitochondria are morphologically dynamic, undergoing continuous shape change through fission and fusion. However, the role of mitochondrial morphology in VSMC migration is not well understood. The aim of the study is to understand how mitochondrial fission contributes to VSMC migration and provides its in vivo relevance in the mouse model of intimal hyperplasia.

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