Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart | Zendy

Kate M. Herum | Zendy; Ida G. Lunde | Zendy; Biljana Skrbic | Zendy; William E. Louch | Zendy; Almira Hasic | Zendy; Sigurd Boye | Zendy; Andreas Unger | Zendy; Sverre-Henning Brorson | Zendy; Ivar Sjaastad | Zendy; Theis Tønnessen | Zendy; Wolfgang A. Linke | Zendy; Maria F. Gomez | Zendy; Geir Christensen | Zendy

Open Access

Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart

Author(s) -

Kate M. Herum,

Ida G. Lunde,

Biljana Skrbic,

William E. Louch,

Almira Hasic,

Sigurd Boye,

Andreas Unger,

Sverre-Henning Brorson,

Ivar Sjaastad,

Theis Tønnessen,

Wolfgang A. Linke,

Maria F. Gomez,

Geir Christensen

Publication year - 2015

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvv002

Subject(s) - syndecan 1 , pressure overload , nfat , myofibroblast , lysyl oxidase , extracellular matrix , microbiology and biotechnology , medicine , endocrinology , osteopontin , cardiac fibrosis , myocyte , chemistry , biology , muscle hypertrophy , fibrosis , calcineurin , biochemistry , cell , transplantation , cardiac hypertrophy

Diastolic dysfunction is central to the development of heart failure. To date, there is no effective treatment and only limited understanding of its molecular basis. Recently, we showed that the transmembrane proteoglycan syndecan-4 increases in the left ventricle after pressure overload in mice and man, and that syndecan-4 via calcineurin/nuclear factor of activated T-cells (NFAT) promotes myofibroblast differentiation and collagen production upon mechanical stress. The aim of this study was to investigate whether syndecan-4 affects collagen cross-linking and myocardial stiffening in the pressure-overloaded heart.

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