Open AccessFGFR1 mediates recombinant thrombomodulin domain-induced angiogenesis
Author(s) -
ChengHsiang Kuo,
Meng-Chen Sung,
Po-Ku Chen,
Bi-Ing Chang,
Fang-Tzu Lee,
Chia-Fong Cho,
Tai-Tzu Hsieh,
Yu-Ching Huang,
Yi-Heng Li,
Guey-Yueh Shi,
Chwan-Yau Luo,
HuaLin Wu
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu239
Subject(s) - angiogenesis , fibroblast growth factor receptor 1 , microbiology and biotechnology , thrombomodulin , fibroblast growth factor , biology , cancer research , chemistry , biochemistry , receptor , immunology , thrombin , platelet
The recombinant epidermal growth factor-like domain plus the serine/threonine-rich domain of thrombomodulin (rTMD23) promotes angiogenesis and accelerates the generation of activated protein C (APC), which facilitates angiogenesis. The aim of this study was to elucidate the molecular mechanisms underlying the angiogenic activity of rTMD23.
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