Open AccessEmergence of Orai3 activity during cardiac hypertrophy
Author(s) -
Youakim Saliba,
Mathilde Keck,
Alexandre Marchand,
Fabrice Atassi,
Aude Ouillé,
Olivier Cazorla,
Mohamed Trebak,
Catherine Pavoine,
Alain Lacampagne,
JeanSébastien Hulot,
Nassim Farès,
Jérémy Fauconnier,
Anne Marie Lompré
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu207
Subject(s) - stim1 , microbiology and biotechnology , orai1 , biology , myocyte , calcium channel , medicine , endocrinology , calcium , endoplasmic reticulum
Stromal interaction molecule 1 (STIM1) has been shown to control a calcium (Ca(2+)) influx pathway that emerges during the hypertrophic remodelling of cardiomyocytes. Our aim was to determine the interaction of Orai1 and Orai3 with STIM1 and their role in the constitutive store-independent and the store-operated, STIM1-dependent, Ca(2+) influx in cardiomyocytes.