Open AccessBalanced changes in Ca buffering by SERCA and troponin contribute to Ca handling during β-adrenergic stimulation in cardiac myocytes
Author(s) -
Sarah J. Briston,
Katharine M. Dibb,
R. John Solaro,
David Eisner,
Andrew W. Trafford
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu201
Subject(s) - serca , stimulation , myocyte , medicine , troponin , troponin i , phosphorylation , endocrinology , adrenergic , troponin c , chemistry , cardiology , biology , biochemistry , receptor , enzyme , myocardial infarction , atpase
During activation of cardiac myocytes, less than 1% of cytosolic Ca is free; the rest is bound to buffers, largely SERCA, and troponin C. Signalling by phosphorylation, as occurs during β-adrenergic stimulation, changes the Ca-binding affinity of these proteins and may affect the systolic Ca transient. Our aim was to determine the effects of β-adrenergic stimulation on Ca buffering and to differentiate between the roles of SERCA and troponin.
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