Influence of the Purkinje-muscle junction on transmural repolarization heterogeneity | Zendy

Richard D. Walton | Zendy; M. Martinez | Zendy; Martin J. Bishop | Zendy; Mélèze Hocini | Zendy; Michel Haı̈ssaguerre | Zendy; Gernot Plank | Zendy; Olivier Bernus | Zendy; Edward J. Vigmond | Zendy

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Influence of the Purkinje-muscle junction on transmural repolarization heterogeneity

Author(s) -

Richard D. Walton,

M. Martinez,

Martin J. Bishop,

Mélèze Hocini,

Michel Haı̈ssaguerre,

Gernot Plank,

Olivier Bernus,

Edward J. Vigmond

Publication year - 2014

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvu165

Subject(s) - repolarization , cardiology , medicine , purkinje fibers , anatomy , neuroscience , electrophysiology , biology

To elucidate the properties of the PMJ and myocardium underlying these effects. Transmural heterogeneity of action potential duration (APD) is known to play an important role in arrhythmogenesis. Regions of non-uniformities of APD gradients often overlap considerably with the location of Purkinje-muscle junctions (PMJs). We therefore hypothesized that such junctions are novel sources of local endocardial and transmural heterogeneity of repolarization, and that remodelling due to heart failure modulates this response.

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