Open AccessMicroRNA-125b protects against myocardial ischaemia/reperfusion injury via targeting p53-mediated apoptotic signalling and TRAF6
Author(s) -
Xiaohui Wang,
Tuanzhu Ha,
Jianghuan Zou,
Danyang Ren,
Li Liu,
Xia Zhang,
John H. Kalbfleisch,
Xiang Gao,
David L. Williams,
Chuanfu Li
Publication year - 2014
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvu044
Subject(s) - apoptosis , medicine , reperfusion injury , transfection , ischemia , myocardial infarction , western blot , endocrinology , chemistry , biochemistry , gene
The present study examined the role of microRNA-125b (miR-125b) in myocardial ischaemia/reperfusion (I/R) injury. We constructed lentivirus-expressing miR-125b (LmiR-125b) and developed transgenic mice with overexpression of miR-125b.
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