B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy | Zendy

Nadine Kramann | Zendy; Gerd Hasenfuß | Zendy; Tim Seidler | Zendy

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B-RAF and its novel negative regulator reticulocalbin 1 (RCN1) modulates cardiomyocyte hypertrophy

Author(s) -

Nadine Kramann,

Gerd Hasenfuß,

Tim Seidler

Publication year - 2014

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvu024

Subject(s) - activator (genetics) , regulator , muscle hypertrophy , microbiology and biotechnology , kinase , cardiac hypertrophy , myocyte , medicine , cancer research , biology , endocrinology , chemistry , biochemistry , gene , receptor

Activation of the kinase RAF and its downstream targets leads to cardiomyocyte hypertrophy. It has been hypothesized that B-RAF might be the main activator of MEK in various cell types. Therefore, the aim of this study was to investigate the role of B-RAF and its modulating factors in cardiomyocyte hypertrophy.

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