Open AccessCalcimimetics increase CaSR expression and reduce mineralization in vascular smooth muscle cells: mechanisms of action
Author(s) -
Lucie Hénaut,
Cédric Boudot,
Ziad A. Massy,
Irene LopezFernandez,
Sébastien Dupont,
Aurélien Mary,
Tilman B. Drüeke,
Saı̈d Kamel,
Michel Brazier,
Romuald Mentaverri
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt249
Subject(s) - calcium sensing receptor , endocrinology , medicine , vascular smooth muscle , calcimimetic , parathyroid chief cell , cinacalcet , chemistry , parathyroid hormone , calcium , secondary hyperparathyroidism , biology , smooth muscle
Vascular calcification (VC) contributes to morbidity and mortality in patients with chronic kidney disease (CKD). Allosteric modulators of the calcium (Ca)-sensing receptor (CaSR) may slow the progression of VC in CKD patients either by reducing serum parathyroid hormone (PTH), Ca, and phosphate levels or by a direct effect on the vessel wall. The aim of this study was to examine the effects of calcimimetics on CaSR expression, cell phenotype, and mineral deposition in human vascular smooth muscle cells (h-VSMCs).
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