Migratory activity of circulating progenitor cells and serum SDF-1α predict adverse events in patients with myocardial infarction | Zendy

Orazio Fortunato | Zendy; Gaia Spinetti | Zendy; Claudia Specchia | Zendy; Elisa Cangiano | Zendy; Marco Valgimigli | Zendy; Paolo Madeddu | Zendy

Open Access

Migratory activity of circulating progenitor cells and serum SDF-1α predict adverse events in patients with myocardial infarction

Author(s) -

Orazio Fortunato,

Gaia Spinetti,

Claudia Specchia,

Elisa Cangiano,

Marco Valgimigli,

Paolo Madeddu

Publication year - 2013

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvt153

Subject(s) - medicine , myocardial infarction , heart failure , progenitor cell , cardiology , adverse effect , bone marrow , immunology , stem cell , biology , genetics

Following acute myocardial infarction (AMI), pro-angiogenic progenitor cells (PCs) are released from the bone marrow into the circulation and home to the ischaemic site attracted by a chemokine gradient. It is unknown if components of this early homeostatic response might help forecast the long-term clinical outcome. This study investigates if the number and migratory activity of circulating PCs predict adverse events in patients with AMI (clinical trial: NCT01271309).

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