Open AccessInhibition of AP-1 signaling by JDP2 overexpression protects cardiomyocytes against hypertrophy and apoptosis induction
Author(s) -
Christian Hill,
Alona Würfel,
Jacqueline Heger,
Bettina Meyering,
KlausDieter Schlüter,
Martin Weber,
Péter Ferdinandy,
Ami Aronheim,
Rainer Schulz,
Gerhild Euler
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt094
Subject(s) - apoptosis , muscle hypertrophy , stimulation , heart failure , medicine , endocrinology , cardiac function curve , cardiac hypertrophy , chemistry , microbiology and biotechnology , cardiology , biology , biochemistry
Expression and activity of the transcription factor AP-1 are enhanced during cardiac remodelling and heart failure progression. In order to test if AP-1 inhibition may limit processes contributing to cardiac remodelling, ventricular cardiomyocytes of mice with cardiac overexpression of the AP-1 inhibitor JDP2 were analysed under stimulation of hypertrophy, apoptosis, or contractile function.
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