Open AccessAICAR inhibits PPARγ during monocyte differentiation to attenuate inflammatory responses to atherogenic lipids
Author(s) -
Dmitry Namgaladze,
Marina Kemmerer,
Andreas von Knethen,
Bernhard Brüne
Publication year - 2013
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvt073
Subject(s) - cd36 , protein kinase a , peroxisome proliferator activated receptor , ampk , monocyte , chemistry , endocrinology , medicine , activator (genetics) , kinase , biology , receptor , microbiology and biotechnology , biochemistry , immunology
Transcriptional regulation through peroxisome proliferator-activated receptor γ (PPARγ) is critical for an altered lipid metabolism during monocyte to macrophage differentiation. Here, we investigated how 5-aminoimidazole-4-carboxamide riboside (AICAR), an activator of AMP-dependent protein kinase (AMPK), affects PPARγ during monocyte differentiation.
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