Prolonged vasoconstriction of resistance arteries involves vascular smooth muscle actin polymerization leading to inward remodelling | Zendy

Marius C. Staiculescu | Zendy; Edgar Luis Galiñanes | Zendy; Guiling Zhao | Zendy; Uri Ulloa | Zendy; Minshan Jin | Zendy; Mirza Irfan Beig | Zendy; Gerald A. Meininger | Zendy; Luis A. MartinezLemus | Zendy

Open Access

Prolonged vasoconstriction of resistance arteries involves vascular smooth muscle actin polymerization leading to inward remodelling

Author(s) -

Marius C. Staiculescu,

Edgar Luis Galiñanes,

Guiling Zhao,

Uri Ulloa,

Minshan Jin,

Mirza Irfan Beig,

Gerald A. Meininger,

Luis A. MartinezLemus

Publication year - 2013

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvt034

Subject(s) - vasoconstriction , rhoa , actin cytoskeleton , microbiology and biotechnology , actin remodeling , actin , cytoskeleton , chemistry , biology , biophysics , endocrinology , biochemistry , signal transduction , cell

Inward remodelling of the resistance vasculature is predictive of hypertension and life-threatening cardiovascular events. We hypothesize that the contractile mechanisms responsible for maintaining a reduced diameter over time in response to prolonged stimulation with vasoconstrictor agonists are in part responsible for the initial stages of the remodelling process. Here we investigated the role of vascular smooth muscle (VSM) actin polymerization on agonist-induced vasoconstriction and development of inward remodelling.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research