Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout | Zendy

Lin Yao | Zendy; Surabhi Chandra | Zendy; Haroldo A. Toque | Zendy; Anil Kumar Bhatta | Zendy; Modesto Rojas | Zendy; Ruth B. Caldwell | Zendy; R. William Caldwell | Zendy

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Prevention of diabetes-induced arginase activation and vascular dysfunction by Rho kinase (ROCK) knockout

Author(s) -

Lin Yao,

Surabhi Chandra,

Haroldo A. Toque,

Anil Kumar Bhatta,

Modesto Rojas,

Ruth B. Caldwell,

R. William Caldwell

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs371

Subject(s) - arginase , diabetes mellitus , rock2 , rock1 , medicine , endocrinology , rho associated protein kinase , endothelial dysfunction , nitric oxide , streptozotocin , nitric oxide synthase , knockout mouse , endothelium , diabetic angiopathy , type 2 diabetes , chemistry , kinase , protein kinase a , arginine , biochemistry , receptor , amino acid

We determined the role of the Rho kinase (ROCK) isoforms in diabetes-induced vascular endothelial dysfunction and enhancement of arginase activity and expression.

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