β-Sitosterol oxidation products attenuate vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2 | Zendy

Chao Yang | Zendy; ZhenYu Chen | Zendy; Siu Ling Wong | Zendy; Jian Liu | Zendy; Yin Liang | Zendy; Chi Wai Lau | Zendy; Hung Kay Lee | Zendy; Yü Huang | Zendy; Suk Ying Tsang | Zendy

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β-Sitosterol oxidation products attenuate vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2

Author(s) -

Chao Yang,

ZhenYu Chen,

Siu Ling Wong,

Jian Liu,

Yin Liang,

Chi Wai Lau,

Hung Kay Lee,

Yü Huang,

Suk Ying Tsang

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs370

Subject(s) - reactive oxygen species , cyclooxygenase , oxygen , chemistry , pharmacology , medicine , biochemistry , organic chemistry , enzyme

β-Sitosterol has become a popular cholesterol-lowering functional food product worldwide. β-Sitosterol can be oxidized to β-sitosterol oxidation products (SOPs) during food processing. Little is known about the impact of SOPs and β-sitosterol on the functionality of arteries. This study investigated the effects of SOPs and β-sitosterol on vasorelaxation and the possible cellular mechanisms involved.

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