Open AccessThe lysosomal transfer of LDL/cholesterol from macrophages into vascular smooth muscle cells induces their phenotypic alteration
Author(s) -
Sönke Weinert,
David M. Poitz,
Susanne Auffermann-Gretzinger,
Lars Eger,
Joerg Herold,
Senad Medunjanin,
Alexander Schmeißer,
Ruth H. Strasser,
Ruediger C. BraunDullaeus
Publication year - 2012
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvs367
Subject(s) - phenotype , vascular smooth muscle , cholesterol , microbiology and biotechnology , chemistry , myocyte , medicine , smooth muscle , macrophage , endocrinology , biology , biochemistry , in vitro , gene
Macrophages (MPs) and vascular smooth muscle cells (VSMCs) closely interact within the growing atherosclerotic plaque. An in vitro co-culture model was established to study how MPs modulate VSMC behaviour.
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