Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury | Zendy

Xiaohui Wang | Zendy; Tuanzhu Ha | Zendy; Li Liu | Zendy; Jianghuan Zou | Zendy; Xia Zhang | Zendy; John H. Kalbfleisch | Zendy; Xiang Gao | Zendy; David L. Williams | Zendy; Chuanfu Li | Zendy

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Increased expression of microRNA-146a decreases myocardial ischaemia/reperfusion injury

Author(s) -

Xiaohui Wang,

Tuanzhu Ha,

Li Liu,

Jianghuan Zou,

Xia Zhang,

John H. Kalbfleisch,

Xiang Gao,

David L. Williams,

Chuanfu Li

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs356

Subject(s) - transfection , medicine , apoptosis , reperfusion injury , ischemia , tumor necrosis factor alpha , myocardial infarction , tlr4 , ejection fraction , receptor , endocrinology , cardiology , chemistry , heart failure , gene , biochemistry

We have reported that either toll-like receptor 4 deficiency (TLR4(-/-)) or TLR2 modulation protects against myocardial ischaemia/reperfusion (I/R) injury. The mechanisms involve attenuation of I/R-induced nuclear factor KappaB (NF-κB) activation. MicroRNA-146a (miR-146a) has been reported to target interleukin-1 receptor-associated kinase 1 (IRAK1) and tumor necrosis factor (TNF) receptor associated factor 6 (TRAF6), resulting in inhibiting NF-κB activation. This study examined the role of microRNA-146a in myocardial I/R injury.

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