PRSS23 is essential for the Snail-dependent endothelial-to-mesenchymal transition during valvulogenesis in zebrafish | Zendy

IHui Chen | Zendy; Hsueh-Hsiao Wang | Zendy; Yi-Shan Hsieh | Zendy; WeiChang Huang | Zendy; HungI Yeh | Zendy; YungJen Chuang | Zendy

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PRSS23 is essential for the Snail-dependent endothelial-to-mesenchymal transition during valvulogenesis in zebrafish

Author(s) -

IHui Chen,

Hsueh-Hsiao Wang,

Yi-Shan Hsieh,

WeiChang Huang,

HungI Yeh,

YungJen Chuang

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs355

Subject(s) - zebrafish , biology , gene knockdown , heart development , snail , morpholino , microbiology and biotechnology , morphogenesis , embryonic stem cell , genetics , gene , ecology

Cardiac valve disease is a common cause of congenital heart failure. Cardiac valve development requires a complex regulation of assorted protease activities. Nevertheless, the regulation of these proteases during atrioventricular (AV) valve formation is poorly understood. Previously, PRSS23, a novel vascular protease, is shown to be highly expressed at the AV canal during murine heart development; however, its function remains unknown. In this study, we sought to characterize the functional role of PRSS23 during cardiac valve formation.

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