Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice | Zendy

Wuzhou Wan | Zendy; Michail S. Lionakis | Zendy; Qian Liu | Zendy; Ester Roffê | Zendy; Philip M. Murphy | Zendy

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Genetic deletion of chemokine receptor Ccr7 exacerbates atherogenesis in ApoE-deficient mice

Author(s) -

Wuzhou Wan,

Michail S. Lionakis,

Qian Liu,

Ester Roffê,

Philip M. Murphy

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs349

Subject(s) - ccl19 , ccl21 , apolipoprotein e , c c chemokine receptor type 7 , cc chemokine receptors , chemokine receptor , chemokine , cx3cr1 , biology , immunology , receptor , medicine , microbiology and biotechnology , disease

Recent evidence suggests that both Ccr7 and its ligands, Ccl19 and Ccl21, are present in mouse and human atherosclerotic plaques; however, the role of Ccr7 in atherogenesis is still controversial. Here, we addressed this question by using the classic apolipoprotein E-deficient (ApoE(-/-)) mouse model of atherosclerosis.

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