Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells | Zendy

Maureen Wanjare | Zendy; Frederick H. Kuo | Zendy; Sharon Gerecht | Zendy

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Derivation and maturation of synthetic and contractile vascular smooth muscle cells from human pluripotent stem cells

Author(s) -

Maureen Wanjare,

Frederick H. Kuo,

Sharon Gerecht

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs315

Subject(s) - induced pluripotent stem cell , phenotype , vascular smooth muscle , microbiology and biotechnology , biology , stem cell , precursor cell , phenotypic switching , smooth muscle , embryonic stem cell , cell , endocrinology , genetics , gene

Embryonic vascular smooth muscle cells (vSMCs) have a synthetic phenotype; in adults, they commit to the mature contractile phenotype. Research shows that human pluripotent stem cells (hPSCs) differentiate into vSMCs, but nobody has yet documented their maturation into the synthetic or contractile phenotypes. This study sought to control the fate decisions of hPSC derivatives to guide their maturation towards a desired phenotype.

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