Voltage-activated Ca2+ channels in rat renal afferent and efferent myocytes: no evidence for the T-type Ca2+ current | Zendy

Smirnov Sv | Zendy; Kathy Loutzenhiser | Zendy; Rodger Loutzenhiser | Zendy

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Voltage-activated Ca2+ channels in rat renal afferent and efferent myocytes: no evidence for the T-type Ca2+ current

Author(s) -

Smirnov Sv,

Kathy Loutzenhiser,

Rodger Loutzenhiser

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs310

Subject(s) - efferent , afferent arterioles , nifedipine , myocyte , arteriole , chemistry , patch clamp , voltage dependent calcium channel , biophysics , endocrinology , medicine , electrophysiology , afferent , calcium , anatomy , biology , biochemistry , circulatory system , receptor , angiotensin ii

Based on indirect methods, it has been suggested that both L- and T-type Ca(2+) channels mediate signalling in the renal afferent arteriole and that T-type Ca(2+) channels are involved in signalling in the efferent arteriole. However, Ca(2+) currents have never been studied in these two vessels. Our study was initiated to directly determine the type of Ca(2+) channels in these vessels for the first time, using patch clamp.

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