Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation | Zendy

Tokuo Saito | Zendy; Yutaka Hasegawa | Zendy; Yasushi Ishigaki | Zendy; Tetsuya Yamada | Zendy; Junhong Gao | Zendy; Junta Imai | Zendy; Kenji Uno | Zendy; Keizo Kaneko | Zendy; Takehide Ogihara | Zendy; Tatsuo Shimosawa | Zendy; Tomoichiro Asano | Zendy; Toshiro Fujita | Zendy; Yoshitomo Oka | Zendy; Hideki Katagiri | Zendy

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Importance of endothelial NF-κB signalling in vascular remodelling and aortic aneurysm formation

Author(s) -

Tokuo Saito,

Yutaka Hasegawa,

Yasushi Ishigaki,

Tetsuya Yamada,

Junhong Gao,

Junta Imai,

Kenji Uno,

Keizo Kaneko,

Takehide Ogihara,

Tatsuo Shimosawa,

Tomoichiro Asano,

Toshiro Fujita,

Yoshitomo Oka,

Hideki Katagiri

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs298

Subject(s) - adventitia , endothelium , inflammation , cell adhesion molecule , endothelial activation , aorta , microbiology and biotechnology , medicine , immunology , biology , pathology

Vascular remodelling and aortic aneurysm formation are induced mainly by inflammatory responses in the adventitia and media. However, relatively little is known about the mechanistic significance of endothelium in the pathogenesis of these vascular disorders. The transcription factor nuclear factor-kappa B (NF-κB) regulates the expressions of numerous genes, including those related to pro-inflammatory responses. Therefore, to investigate the roles of endothelial pro-inflammatory responses, we examined the impact of blocking endothelial NF-κB signalling on intimal hyperplasia and aneurysm formation.

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