Macrophage migration inhibitory factor in the nucleus of solitary tract decreases blood pressure in SHRs | Zendy

André Henrique Freiria-Oliveira | Zendy; Graziela Torres Blanch | Zendy; Hongwei Li | Zendy; Eduardo Colombari | Zendy; Débora S.A. Colombari | Zendy; Colin Sumners | Zendy

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Macrophage migration inhibitory factor in the nucleus of solitary tract decreases blood pressure in SHRs

Author(s) -

André Henrique Freiria-Oliveira,

Graziela Torres Blanch,

Hongwei Li,

Eduardo Colombari,

Débora S.A. Colombari,

Colin Sumners

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs297

Subject(s) - macrophage migration inhibitory factor , blood pressure , inhibitory postsynaptic potential , macrophage , nucleus , medicine , immunology , endocrinology , biology , chemistry , microbiology and biotechnology , in vitro , cytokine , biochemistry

The macrophage migration inhibitory factor (MIF) is an intracellular inhibitor of the central nervous system actions of angiotensin II on blood pressure. Considering that angiotensin II actions at the nucleus of the solitary tract are important for the maintenance of hypertension in spontaneously hypertensive rats (SHRs), we tested if increased MIF expression in the nucleus of the solitary tract of SHR alters the baseline high blood pressure in these rats.

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