Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity | Zendy

Alessandra Ruggiero | Zendy; Suet Nee Chen | Zendy; Raffaella Lombardi | Zendy; Gabriela Rodrı́guez | Zendy; Ali J. Marian | Zendy

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Pathogenesis of hypertrophic cardiomyopathy caused by myozenin 2 mutations is independent of calcineurin activity

Author(s) -

Alessandra Ruggiero,

Suet Nee Chen,

Raffaella Lombardi,

Gabriela Rodrı́guez,

Ali J. Marian

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs294

Subject(s) - calcineurin , transgene , genetically modified mouse , biology , mutant , pathogenesis , microbiology and biotechnology , endocrinology , medicine , gene , immunology , genetics , transplantation

The role of calcineurin protein phosphatase 2B (PP2B) in the pathogenesis of human hypertrophic cardiomyopathy (HCM) remains unsettled. We determined potential involvement of calcineurin in the pathogenesis of HCM caused by mutations in myozenin 2 (MYOZ2), an inhibitor of calcineurin.

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