Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes | Zendy

Rajesh Katare | Zendy; Atsuhiko Oikawa | Zendy; Daniela Cesselli | Zendy; Antonio Paolo Beltrami | Zendy; Elisa Avolio | Zendy; Deepti Muthukrishnan | Zendy; Pujika Emani Munasinghe | Zendy; Gianni D. Angelini | Zendy; Costanza Emanueli | Zendy; Paolo Madeddu | Zendy

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Boosting the pentose phosphate pathway restores cardiac progenitor cell availability in diabetes

Author(s) -

Rajesh Katare,

Atsuhiko Oikawa,

Daniela Cesselli,

Antonio Paolo Beltrami,

Elisa Avolio,

Deepti Muthukrishnan,

Pujika Emani Munasinghe,

Gianni D. Angelini,

Costanza Emanueli,

Paolo Madeddu

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs291

Subject(s) - pentose phosphate pathway , biology , protein kinase b , microbiology and biotechnology , progenitor cell , pi3k/akt/mtor pathway , stem cell , cancer research , signal transduction , biochemistry , glycolysis , enzyme

Diabetes impinges upon mechanisms of cardiovascular repair. However, the biochemical adaptation of cardiac stem cells to sustained hyperglycaemia remains largely unknown. Here, we investigate the molecular targets of high glucose-induced damage in cardiac progenitor cells (CPCs) from murine and human hearts and attempt safeguarding CPC viability and function through reactivation of the pentose phosphate pathway.

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