Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms | Zendy

Saïd F.A. Askar | Zendy; Brian O. Bingen | Zendy; Martin J. Schalij | Zendy; Jim Swildens | Zendy; Douwe E. Atsma | Zendy; Cindy I. Schutte | Zendy; Antoine A.F. de Vries | Zendy; Katja Zeppenfeld | Zendy; Dirk L. Ypey | Zendy; Daniël A. Pijnappels | Zendy

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Similar arrhythmicity in hypertrophic and fibrotic cardiac cultures caused by distinct substrate-specific mechanisms

Author(s) -

Saïd F.A. Askar,

Brian O. Bingen,

Martin J. Schalij,

Jim Swildens,

Douwe E. Atsma,

Cindy I. Schutte,

Antoine A.F. de Vries,

Katja Zeppenfeld,

Dirk L. Ypey,

Daniël A. Pijnappels

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs290

Subject(s) - fibrosis , muscle hypertrophy , medicine , repolarization , phenylephrine , myofibroblast , afterdepolarization , myocardial fibrosis , cardiology , endocrinology , electrophysiology , blood pressure

Cardiac hypertrophy and fibrosis are associated with potentially lethal arrhythmias. As these substrates often occur simultaneously in one patient, distinguishing between pro-arrhythmic mechanisms is difficult. This hampers understanding of underlying pro-arrhythmic mechanisms and optimal treatment. This study investigates and compares arrhythmogeneity and underlying pro-arrhythmic mechanisms of either cardiac hypertrophy or fibrosis in in vitro models.

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