Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation | Zendy

Changjun Yang | Zendy; M.A. Hassan Talukder | Zendy; Saradhadevi Varadharaj | Zendy; V. Murugesan | Zendy; Jay L. Zweíer | Zendy

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Early ischaemic preconditioning requires Akt- and PKA-mediated activation of eNOS via serine1176 phosphorylation

Author(s) -

Changjun Yang,

M.A. Hassan Talukder,

Saradhadevi Varadharaj,

V. Murugesan,

Jay L. Zweíer

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs287

Subject(s) - enos , endothelial nitric oxide synthase , protein kinase b , nitric oxide , phosphorylation , nitric oxide synthase , endothelial nos , medicine , microbiology and biotechnology , enzyme activator , nitric oxide synthase type iii , chemistry , endocrinology , biology

The role of endothelial nitric oxide synthase (eNOS)/NO signalling is well documented in late ischaemic preconditioning (IPC); however, the role of eNOS and its activation in early IPC remains controversial. This study investigates the role of eNOS in early IPC and the signalling pathways and molecular interactions that regulate eNOS activation during early IPC.

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