Open AccessLack of ecto-5′-nucleotidase (CD73) promotes arteriogenesis
Author(s) -
Yang Chul Böring,
Ulrich Flögel,
Christoph Jacoby,
Matthias Heil,
Wolfgang Schäper,
Jürgen Schrader
Publication year - 2012
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvs286
Subject(s) - arteriogenesis , hindlimb , angiogenesis , 5' nucleotidase , adenosine , medicine , ischemia , anatomy , endocrinology , pathology , microbiology and biotechnology , biology
Adenosine can stimulate angiogenesis, but its role in the distinct process of arteriogenesis is unknown. We have previously reported that mice lacking ecto-5'-nucleotidase (CD73-/-) show enhanced monocyte adhesion to the endothelium after ischaemia, which is considered to be an important trigger for arteriogenesis.
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