The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C | Zendy

Julia Schiekel | Zendy; Moritz Lindner | Zendy; Andrea Hetzel | Zendy; Konstantin Wemhöner | Zendy; Vijay Renigunta | Zendy; Günter Schlichthörl | Zendy; Niels Decher | Zendy; Dominik Oliver | Zendy; Jürgen Daut | Zendy

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The inhibition of the potassium channel TASK-1 in rat cardiac muscle by endothelin-1 is mediated by phospholipase C

Author(s) -

Julia Schiekel,

Moritz Lindner,

Andrea Hetzel,

Konstantin Wemhöner,

Vijay Renigunta,

Günter Schlichthörl,

Niels Decher,

Dominik Oliver,

Jürgen Daut

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs285

Subject(s) - phospholipase c , endothelin receptor , endothelin 1 , receptor , potassium channel , gq alpha subunit , signal transduction , biology , microbiology and biotechnology , protein kinase c , medicine , patch clamp , endocrinology , biophysics , chemistry , pharmacology , g protein , biochemistry

The two-pore-domain potassium channel TASK-1 is robustly inhibited by the activation of receptors coupled to the Gα(q) subgroup of G-proteins, but the signal transduction pathway is still unclear. We have studied the mechanisms by which endothelin receptors inhibit the current carried by TASK-1 channels (I(TASK)) in cardiomyocytes.

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