FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Krüppel-like factor 2 | Zendy

HaeYoung Lee | Zendy; SeockWon Youn | Zendy; HyunJai Cho | Zendy; YooWook Kwon | Zendy; Sae-Won Lee | Zendy; SungJin Kim | Zendy; Young-Bae Park | Zendy; ByungHee Oh | Zendy; Hyo-Soo Kim | Zendy

Open Access

FOXO1 impairs whereas statin protects endothelial function in diabetes through reciprocal regulation of Krüppel-like factor 2

Author(s) -

HaeYoung Lee,

SeockWon Youn,

HyunJai Cho,

YooWook Kwon,

Sae-Won Lee,

SungJin Kim,

Young-Bae Park,

ByungHee Oh,

Hyo-Soo Kim

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs283

Subject(s) - klf2 , foxo1 , atorvastatin , medicine , endocrinology , statin , endothelial dysfunction , endothelium , chemistry , transcription factor , biology , protein kinase b , microbiology and biotechnology , phosphorylation , biochemistry , gene

Krüppel-like factor 2 (KLF2) is implicated as a key molecule maintaining endothelial function. This study was designed to evaluate the reciprocal regulation of KLF2 by the forkhead transcription factor FOXO1, and the 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitor atorvastatin, in hyperglycaemic conditions.

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