17β-Estradiol-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes | Zendy

Shokoufeh Mahmoodzadeh | Zendy; Thi Hang Pham | Zendy; Arne Kuehne | Zendy; Britta Fielitz | Zendy; Elke Dworatzek | Zendy; Georgios Kararigas | Zendy; George Petrov | Zendy; Mercy M. Davidson | Zendy; Vera RegitzZagrosek | Zendy

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17β-Estradiol-induced interaction of ERα with NPPA regulates gene expression in cardiomyocytes

Author(s) -

Shokoufeh Mahmoodzadeh,

Thi Hang Pham,

Arne Kuehne,

Britta Fielitz,

Elke Dworatzek,

Georgios Kararigas,

George Petrov,

Mercy M. Davidson,

Vera RegitzZagrosek

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs281

Subject(s) - microbiology and biotechnology , biology , chromatin immunoprecipitation , transcription factor , receptor , medicine , gene expression , gene , genetics , promoter

17β-Oestradiol (E2) and its receptors (ERα and ERβ) are important regulators of physiological and pathological processes in the cardiovascular system. ER act in concert with other regulatory factors mediating oestrogenic effects. However, the underlying mechanisms modulating ER transcriptional activity are not fully elucidated. To gain better understanding of E2-induced ERα action in the human heart, we aimed to identify and functionally analyse interaction partners of ERα.

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