Induction of intracellular heat-shock protein 72 prevents the development of vascular smooth muscle cell calcification | Zendy

Tzongshi Lu | Zendy; Kenneth Lim | Zendy; Guerman Molostvov | Zendy; YunChun Yang | Zendy; SzuYu Yiao | Zendy; Daniel Zehnder | Zendy; LiLi Hsiao | Zendy

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Induction of intracellular heat-shock protein 72 prevents the development of vascular smooth muscle cell calcification

Author(s) -

Tzongshi Lu,

Kenneth Lim,

Guerman Molostvov,

YunChun Yang,

SzuYu Yiao,

Daniel Zehnder,

LiLi Hsiao

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs278

Subject(s) - heat shock protein , vascular smooth muscle , myocardin , gene knockdown , calcification , medicine , myocyte , pathogenesis , biology , microbiology and biotechnology , endocrinology , cancer research , gene expression , gene , serum response factor , biochemistry , smooth muscle

Vascular calcification (VC) is a significant contributor to cardiovascular mortality in patients with chronic kidney disease (CKD) and coronary artery disease (CAD). Osteo/chondrocytic transformation and simultaneous dedifferentiation of smooth muscle cells (SMCs) are important in the pathogenesis of VC. Heat-shock protein 72 (HSP72) is a cardioprotective inducible heat-shock protein that functions as a molecular chaperone. However, its role in the development of accelerated vascular dysfunction and calcification is largely unexplored.

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