Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein | Zendy

Livius V. d’Uscio | Zendy; Pritam Das | Zendy; Anantha V. Santhanam | Zendy; Tongrong He | Zendy; Steven G. Younkin | Zendy; Zvonimir S. Katušić | Zendy

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Activation of PPARδ prevents endothelial dysfunction induced by overexpression of amyloid-β precursor protein

Author(s) -

Livius V. d’Uscio,

Pritam Das,

Anantha V. Santhanam,

Tongrong He,

Steven G. Younkin,

Zvonimir S. Katušić

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs266

Subject(s) - superoxide , endothelial dysfunction , nadph oxidase , endocrinology , chemistry , amyloid precursor protein , medicine , superoxide dismutase , nitric oxide , endothelium , tetrahydrobiopterin , oxidative stress , nitric oxide synthase , biology , biochemistry , alzheimer's disease , disease , enzyme

Existing evidence suggests that amyloid-β precursor protein (APP) causes endothelial dysfunction and contributes to pathogenesis of atherosclerosis. In the present study, experiments were designed to: (1) determine the mechanisms underlying endothelial dysfunction and (2) define the effects of peroxisome proliferator-activated receptor delta (PPARδ) ligand on endothelial function in transgenic Tg2576 mice overexpressing mutated human APP.

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