α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy | Zendy

Ilana TaliorVolodarsky | Zendy; Kim A. Connelly | Zendy; Pamma D. Arora | Zendy; Donald Gullberg | Zendy; Christopher A. McCulloch | Zendy

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α11 integrin stimulates myofibroblast differentiation in diabetic cardiomyopathy

Author(s) -

Ilana TaliorVolodarsky,

Kim A. Connelly,

Pamma D. Arora,

Donald Gullberg,

Christopher A. McCulloch

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs259

Subject(s) - myofibroblast , diabetic cardiomyopathy , integrin , cardiomyopathy , medicine , microbiology and biotechnology , biology , receptor , heart failure , fibrosis

Diabetic cardiomyopathy is characterized by the production of a disorganized fibrotic matrix in the absence of coronary atherosclerosis and hypertension. We examined whether adhesion of cardiac fibroblasts to glycated collagens mediates the differentiation of pro-fibrotic myofibroblasts, which may contribute to cardiac fibrosis.

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