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MicroRNA-204 regulates vascular smooth muscle cell calcification in vitro and in vivo
Author(s) -
Rongrong Cui,
S.-J. Li,
L.-J. Liu,
Yi Liang,
Liang Qin,
Xiangcheng Zhu,
G. Liu,
Yang Liu,
Shanshan Wu,
XiaoBo Liao,
LingQing Yuan,
Ding-An Mao
Publication year - 2012
Publication title -
cardiovascular research
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.774
H-Index - 219
eISSN - 1755-3245
pISSN - 0008-6363
DOI - 10.1093/cvr/cvs258
Subject(s) - calcification , vascular smooth muscle , runx2 , microrna , biology , microbiology and biotechnology , transfection , medicine , endocrinology , chemistry , cell culture , osteoblast , in vitro , biochemistry , smooth muscle , genetics , gene
Medial artery calcification is a common macroangiopathy that initiates from a cell-regulated process similar to osteogenesis. Although the mechanisms governing this process remain unclear, epigenomic regulation by specific microRNAs might play a role in vascular smooth muscle cell (VSMC) calcification. In this study, we aimed to investigate whether miR-204 participates in the regulation of VSMC calcification.

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