β2-Integrin and Notch-1 differentially regulate CD34+CD31+ cell plasticity in vascular niches | Zendy

Yu-Tsung Shih | Zendy; Mei-Cun Wang | Zendy; Tung-Lin Yang | Zendy; Jing Zhou | Zendy; Ding-Yu Lee | Zendy; Pei-Ling Lee | Zendy; ShawFang Yet | Zendy; JengJiann Chiu | Zendy

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β2-Integrin and Notch-1 differentially regulate CD34+CD31+ cell plasticity in vascular niches

Author(s) -

Yu-Tsung Shih,

Mei-Cun Wang,

Tung-Lin Yang,

Jing Zhou,

Ding-Yu Lee,

Pei-Ling Lee,

ShawFang Yet,

JengJiann Chiu

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs256

Subject(s) - microbiology and biotechnology , cd31 , progenitor cell , biology , haematopoiesis , plasticity , cd34 , notch signaling pathway , integrin , endothelial stem cell , stem cell , angiogenesis , cell , immunology , signal transduction , cancer research , genetics , physics , in vitro , thermodynamics

The implication of circulating haematopoietic CD34(+) progenitors in the vasculature is unclear due to the lack of understanding of their characteristics and plasticity mediated by their cellular microenvironment. We investigated how vascular smooth muscle cells (SMCs) and their interactions with endothelial cells (ECs) affect the behaviour and plasticity of CD34(+)CD31(+) progenitors and the underlying mechanisms.

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