Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates | Zendy

Vivek K. Bajpai | Zendy; Panagiotis Mistriotis | Zendy; YuinHan Loh | Zendy; George Q. Daley | Zendy; Stelios T. Andreadis | Zendy

Open Access

Functional vascular smooth muscle cells derived from human induced pluripotent stem cells via mesenchymal stem cell intermediates

Author(s) -

Vivek K. Bajpai,

Panagiotis Mistriotis,

YuinHan Loh,

George Q. Daley,

Stelios T. Andreadis

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs253

Subject(s) - microbiology and biotechnology , mesenchymal stem cell , stem cell , biology , calponin , induced pluripotent stem cell , population , vascular smooth muscle , cellular differentiation , regenerative medicine , directed differentiation , progenitor cell , embryonic stem cell , endocrinology , actin , medicine , genetics , environmental health , smooth muscle , gene

Smooth muscle cells (SMC) play an important role in vascular homeostasis and disease. Although adult mesenchymal stem cells (MSC) have been used as a source of contractile SMC, they suffer from limited proliferation potential and culture senescence, particularly when originating from older donors. By comparison, human induced pluripotent stem cells (hiPSC) can provide an unlimited source of functional SMC for autologous cell-based therapies and for creating models of vascular disease. Our goal was to develop an efficient strategy to derive functional, contractile SMC from hiPSC.

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