Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart | Zendy

Jiwen Yang | Zendy; Sandra Bücker | Zendy; Benno Jungblut | Zendy; Thomas Boettger | Zendy; Yuval Cinnamon | Zendy; Jan S. Tchorz | Zendy; Mathias Müller | Zendy; Bernhard Bettler | Zendy; Richard P. Harvey | Zendy; QingYuan Sun | Zendy; André Schneider | Zendy; Thomas Braun | Zendy

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Inhibition of Notch2 by Numb/Numblike controls myocardial compaction in the heart

Author(s) -

Jiwen Yang,

Sandra Bücker,

Benno Jungblut,

Thomas Boettger,

Yuval Cinnamon,

Jan S. Tchorz,

Mathias Müller,

Bernhard Bettler,

Richard P. Harvey,

QingYuan Sun,

André Schneider,

Thomas Braun

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs250

Subject(s) - numb , notch signaling pathway , microbiology and biotechnology , genetically modified mouse , medicine , biology , embryonic stem cell , transgene , chemistry , endocrinology , anatomy , signal transduction , biochemistry , gene

The ventricular wall of the heart is composed of trabeculated and compact layers, which are separated by yet unknown processes during embryonic development. Here, we wanted to explore the role of Notch2 and Numb/Numblike for myocardial trabeculation and compaction.

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