Chronic potentiation of cardiac L-type Ca2+ channels by pirfenidone | Zendy

Roberto RamosMondragón | Zendy; Carlos A Galindo | Zendy; Maricela GarcíaCastañeda | Zendy; José L. Sánchez-Vargas | Zendy; Ana V. Vega | Zendy; Norma Leticia Gómez-Viquez | Zendy; Guillermo Ávila | Zendy

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Chronic potentiation of cardiac L-type Ca2+ channels by pirfenidone

Author(s) -

Roberto RamosMondragón,

Carlos A Galindo,

Maricela GarcíaCastañeda,

José L. Sánchez-Vargas,

Ana V. Vega,

Norma Leticia Gómez-Viquez,

Guillermo Ávila

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs248

Subject(s) - pirfenidone , chemistry , nitric oxide , nitric oxide synthase , patch clamp , pharmacology , medicine , cyclic adenosine monophosphate , long term potentiation , endocrinology , biophysics , electrophysiology , biology , biochemistry , receptor , idiopathic pulmonary fibrosis , lung

On the basis of its ability to inhibit fibrosis, pirfenidone has drawn the attention as an intriguing candidate for treating cardiac disease. However, its precise electrophysiological effects have yet to be elucidated. Here, we have investigated its potential to modulate ion channels.

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