Coordination of fibronectin adhesion with contraction and relaxation in microvascular smooth muscle | Zendy

Zhongkui Hong | Zendy; Zhe Sun | Zendy; Zhaohui Li | Zendy; Walatta-Tseyon Mesquitta | Zendy; Jerome P. Trzeciakowski | Zendy; Gerald A. Meininger | Zendy

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Coordination of fibronectin adhesion with contraction and relaxation in microvascular smooth muscle

Author(s) -

Zhongkui Hong,

Zhe Sun,

Zhaohui Li,

Walatta-Tseyon Mesquitta,

Jerome P. Trzeciakowski,

Gerald A. Meininger

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs239

Subject(s) - fibronectin , vasodilation , extracellular matrix , vascular smooth muscle , contraction (grammar) , integrin , chemistry , microbiology and biotechnology , biophysics , smooth muscle , medicine , biology , cell , biochemistry

The regulation of vascular diameter by vasoconstrictors and vasodilators requires that vascular smooth muscle cells (VSMCs) be physically coupled to extracellular matrix (ECM) and neighbouring cells in order for a vessel to mechanically function and transfer force. The hypothesis was tested that integrin-mediated adhesion to the ECM is dynamically up-regulated in VSMCs during contractile activation in response to a vasoconstrictor and likewise down-regulated during relaxation in response to a vasodilator.

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