Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction | Zendy

Jonathon Habersberger | Zendy; Frederik Strang | Zendy; Amelie Scheichl | Zendy; Nay Htun | Zendy; Nicole Bassler | Zendy; Ruusu-Maaria Merivirta | Zendy; Philipp Diehl | Zendy; Guy Y. Krippner | Zendy; Peter J. Meikle | Zendy; Steffen U. Eisenhardt | Zendy; Ian T. Meredith | Zendy; Karlheinz Peter | Zendy

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Circulating microparticles generate and transport monomeric C-reactive protein in patients with myocardial infarction

Author(s) -

Jonathon Habersberger,

Frederik Strang,

Amelie Scheichl,

Nay Htun,

Nicole Bassler,

Ruusu-Maaria Merivirta,

Philipp Diehl,

Guy Y. Krippner,

Peter J. Meikle,

Steffen U. Eisenhardt,

Ian T. Meredith,

Karlheinz Peter

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs237

Subject(s) - c reactive protein , myocardial infarction , inflammation , medicine , chemistry

Elevated serum C-reactive protein (CRP) following myocardial infarction (MI) is associated with poor outcomes. Although animal studies have indicated a direct pathogenic role of CRP, the mechanism underlying this remains elusive. Dissociation of pentameric CRP (pCRP) into pro-inflammatory monomers (mCRP) may directly link CRP to inflammation. We investigated whether cellular microparticles (MPs) can convert pCRP to mCRP and transport mCRP following MI.

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