Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity | Zendy

Sevvandi Senadheera | Zendy; Youngsoo Kim | Zendy; Trustees Grayson | Zendy; Sianne Toemoe | Zendy; Mikhail Y. Kochukov | Zendy; Joel Abramowitz | Zendy; Gary D. Housley | Zendy; Rebecca L. Bertrand | Zendy; Preet S. Chadha | Zendy; Paul Bertrand | Zendy; Timothy V. Murphy | Zendy; Marianne Tare | Zendy; Lutz Birnbaumer | Zendy; Sean P. Marrelli | Zendy; Shaun L. Sandow | Zendy

Open Access

Transient receptor potential canonical type 3 channels facilitate endothelium-derived hyperpolarization-mediated resistance artery vasodilator activity

Author(s) -

Sevvandi Senadheera,

Youngsoo Kim,

Trustees Grayson,

Sianne Toemoe,

Mikhail Y. Kochukov,

Joel Abramowitz,

Gary D. Housley,

Rebecca L. Bertrand,

Preet S. Chadha,

Paul Bertrand,

Timothy V. Murphy,

Marianne Tare,

Lutz Birnbaumer,

Sean P. Marrelli,

Shaun L. Sandow

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs208

Subject(s) - trpc3 , electrical impedance myography , transient receptor potential channel , mesenteric arteries , microbiology and biotechnology , biology , endothelium , endocrinology , medicine , vasodilation , receptor , artery , trpc

Microdomain signalling mechanisms underlie key aspects of artery function and the modulation of intracellular calcium, with transient receptor potential (TRP) channels playing an integral role. This study determines the distribution and role of TRP canonical type 3 (C3) channels in the control of endothelium-derived hyperpolarization (EDH)-mediated vasodilator tone in rat mesenteric artery.

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