Ultrastructural remodelling of Ca2+ signalling apparatus in failing heart cells | Zendy

Haodi Wu | Zendy; Ming Xu | Zendy; Rong-Chang Li | Zendy; Liang Guo | Zendy; YingSi Lai | Zendy; Shiming Xu | Zendy; Sufang Li | Zendy; Quanlong Lü | Zendy; Linlin Li | Zendy; Haibo Zhang | Zendy; Youyi Zhang | Zendy; Chuan-Mao Zhang | Zendy; ShiQiang Wang | Zendy

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Ultrastructural remodelling of Ca2+ signalling apparatus in failing heart cells

Author(s) -

Haodi Wu,

Ming Xu,

Rong-Chang Li,

Liang Guo,

YingSi Lai,

Shiming Xu,

Sufang Li,

Quanlong Lü,

Linlin Li,

Haibo Zhang,

Youyi Zhang,

Chuan-Mao Zhang,

ShiQiang Wang

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs195

Subject(s) - ultrastructure , cardiology , medicine , microbiology and biotechnology , biology , anatomy

The contraction of a heart cell is controlled by Ca(2+)-induced Ca(2+) release between L-type Ca(2+) channels (LCCs) in the cell membrane/T-tubules (TTs) and ryanodine receptors (RyRs) in the junctional sarcoplasmic reticulum (SR). During heart failure, LCC-RyR signalling becomes defective. The purpose of the present study was to reveal the ultrastructural mechanism underlying the defective LCC-RyR signalling and contractility.

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