PKCδ signalling regulates SR-A and CD36 expression and foam cell formation | Zendy

ChinSheng Lin | Zendy; FengYen Lin | Zendy; LingJun Ho | Zendy; ChienSung Tsai | Zendy; Shu-Mung Cheng | Zendy; Wan-Lin Wu | Zendy; Chuan-Yueh Huang | Zendy; Chen-Hao Lian | Zendy; Shih-Ping Yang | Zendy; Jenn-Haung Lai | Zendy

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PKCδ signalling regulates SR-A and CD36 expression and foam cell formation

Author(s) -

ChinSheng Lin,

FengYen Lin,

LingJun Ho,

ChienSung Tsai,

Shu-Mung Cheng,

Wan-Lin Wu,

Chuan-Yueh Huang,

Chen-Hao Lian,

Shih-Ping Yang,

Jenn-Haung Lai

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs189

Subject(s) - protein kinase c , protein kinase b , foam cell , mapk/erk pathway , cd36 , rottlerin , microbiology and biotechnology , pi3k/akt/mtor pathway , small interfering rna , small hairpin rna , kinase , chemistry , signal transduction , gene knockdown , biology , cell culture , transfection , biochemistry , receptor , macrophage , apoptosis , genetics , in vitro

The formation of foam cells is crucial in the initiation and progression of atherosclerosis. One of the critical steps in foam cell formation is the uptake of low-density lipoprotein (LDL) by macrophages via scavenger receptors (SRs). This study examined the role of protein kinase C (PKC) isoforms on foam cell formation.

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