Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart | Zendy

F. Hofmann | Zendy; Larissa Fabritz | Zendy; Juliane Stieber | Zendy; Joachim P. Schmitt | Zendy; Paulus Kirchhof | Zendy; A. Ludwig | Zendy; Stefan Herrmann | Zendy

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Ventricular HCN channels decrease the repolarization reserve in the hypertrophic heart

Author(s) -

F. Hofmann,

Larissa Fabritz,

Juliane Stieber,

Joachim P. Schmitt,

Paulus Kirchhof,

A. Ludwig,

Stefan Herrmann

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs184

Subject(s) - medicine , ventricle , repolarization , cardiology , depolarization , muscle hypertrophy , reprogramming , ion channel , hypertrophic cardiomyopathy , left ventricular hypertrophy , biology , electrophysiology , cell , blood pressure , receptor , genetics

Cardiac hypertrophy is accompanied by reprogramming of gene expression, where the altered expression of ion channels decreases electrical stability and increases the risk of life-threatening arrhythmias. However, the underlying mechanisms are not fully understood. Here, we analysed the role of the depolarizing current I(f) which has been hypothesized to contribute to arrhythmogenesis in the hypertrophied ventricle.

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