Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity | Zendy

Jérôme Thireau | Zendy; Sarah Arangurem Karam | Zendy; Jérémy Fauconnier | Zendy; Stéphanie Roberge | Zendy; Cécile Cassan | Zendy; Olivier Cazorla | Zendy; Franck Aimond | Zendy; Alain Lacampagne | Zendy; Dominique Babuty | Zendy; Sylvain Richard | Zendy

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Functional evidence for an active role of B-type natriuretic peptide in cardiac remodelling and pro-arrhythmogenicity

Author(s) -

Jérôme Thireau,

Sarah Arangurem Karam,

Jérémy Fauconnier,

Stéphanie Roberge,

Cécile Cassan,

Olivier Cazorla,

Franck Aimond,

Alain Lacampagne,

Dominique Babuty,

Sylvain Richard

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs167

Subject(s) - medicine , heart failure , brain natriuretic peptide , natriuretic peptide , endocrinology , myocardial infarction , ventricle , cardiology , afterdepolarization , cardiac fibrosis , ventricular remodeling , repolarization , electrophysiology

During heart failure (HF), the left ventricle (LV) releases B-type natriuretic peptide (BNP), possibly contributing to adverse cardiovascular events including ventricular arrhythmias (VAs) and LV remodelling. We investigated the cardiac effects of chronic BNP elevation in healthy mice and compared the results with a model of HF after myocardial infarction (PMI mice).

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