Monocyte chemotactic protein 3 is a homing factor for circulating angiogenic cells | Zendy

Mélanie Bousquenaud | Zendy; Chantal Schwartz | Zendy; Frédérique Léonard | Zendy; Magali Rolland-Turner | Zendy; Daniel Wagner | Zendy; Yvan Devaux | Zendy

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Monocyte chemotactic protein 3 is a homing factor for circulating angiogenic cells

Author(s) -

Mélanie Bousquenaud,

Chantal Schwartz,

Frédérique Léonard,

Magali Rolland-Turner,

Daniel Wagner,

Yvan Devaux

Publication year - 2012

Publication title -

cardiovascular research

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.774

H-Index - 219

eISSN - 1755-3245

pISSN - 0008-6363

DOI - 10.1093/cvr/cvs140

Subject(s) - ccr1 , chemokine , monocyte , stromal cell , chemotaxis , stromal cell derived factor 1 , microbiology and biotechnology , angiogenesis , receptor , chemokine receptor , chemistry , immunology , medicine , cxcr4 , biology

Circulating angiogenic cells (CAC) participate in cardiac repair. CAC recruitment to the ischaemic heart is mainly induced by the chemokine (C-X-C motif) receptor 4 (CXCR4)/stromal-cell derived factor-1α axis. However, CAC mobilization is only partly prevented by CXCR4 blockade, indicating that other mechanisms are involved. Since the expression of monocyte chemotactic protein 3 (MCP3) is increased in ischaemic hearts, we hypothesized that it may participate in CAC mobilization.

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